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GMP CERT

this protein induces a peculiar form of cell death, now called ferroptosis, via an increase in ROS levels that subsequently inhibit the cystine uptake typically mediated by the repression of a key component of the cystine/glutamate antiporter 126

The protein thioredoxin, together with TXNRD1 (or TXNRD3), NADPH, and FAD, constitute the thioredoxin antioxidant system involved in the reduction of antioxidant enzymes (e.g., peroxiredoxins, methionine sulfoxide reductases, and ribonucleotide reductase) and of many oxidation/reduction (redox)-sensitive signaling proteins (9)

Stilley JA, Birt JA, Sharpe-Timms KL (2012) Cellular and molecular basis for endometriosis-associated infertility

Separate-vial workflow Independent dose control Use separate vials when researchers want to titrate each peptide independently, study a non-1:1 ratio, or stop one compound early

doi: 10.1038/35007534